1. Under the Global Settings > Audio tab, ensure that both XLR and 1/4" are selected for Guitar Out.
2. Create a new rig, select the Immediate Split signal path, then tap the MIX button.
3. To make the blocks at the top of the screen output through the right, pan A to -100%.
To make the blocks at the bottom of the screen output through the left, pan B to 100%.
It's important to note that only the blocks which are placed before the mix button will be panned. The blocks which are placed after the mix button will affect both the XLR and 1/4" (left and right) outputs.
4. Place all the FX you want routed to the right XLR output on the top blocks of the screen, then connect an XLR cable to the right XLR output.
Place all the FX you want routed to the left 1/4" output on the bottom blocks of the screen, then connect a 1/4" cable to the left 1/4" output.
You will now hear your single guitar signal being routed to both outputs with different FX applied.